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Medical Definition of Inhibitory synapse
1. A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. The most common inhibitory neurotransmitter is GABA, this opens channels in the postsynaptic cell which tend to stabilise its resting potential, thus rendering it less likely to fire. See: excitatory synapse, presynaptic inhibition, postsynaptic inhibition. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)