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Medical Definition of Hypothalamohypophysial tract
1. A bundle of unmyelinated fibres originating from all cells of the supraoptic nucleus and an estimated 20% of those of the paraventricular nucleus of the hypothalamus, which extend through the infundibulum and pituitary stalk to their endings in the posterior lobe of the hypophysis; the fibres convey neurosecretory substances, vasopressin and oxytocin, which are stored in (and can be released into the circulating blood from) their terminals. See: hypophysis, neurosecretion. Synonym: tractus supraopticohypophysialis, hypothalamohypophysial tract. (05 Mar 2000)