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Medical Definition of Hyposplenism
1. Absent or reduced splenic function, usually due to surgical removal, congenital aplasia, tumour replacement, or splenic vascular accident. Red cell abnormalities, including the presence of inclusions, nucleated erythrocytes, and target cells, are commonly present. Patients with hyposplenism are at increased risk of bacterial sepsis, especially due to pneumococcus. (05 Mar 2000)