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Medical Definition of Hyperreactive malarious splenomegaly
1. A syndrome characterised by persistent splenomegaly, exceptionally high serum IgM and malaria antibody levels, and hepatic sinusoidal lymphocytosis; believed to be a disturbance in the T-lymphocyte control of the humoral response to recurrent malaria. Synonym: tropical splenomegaly syndrome. (05 Mar 2000)