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Medical Definition of Hyperosmolar nonketotic coma
1. A complication seen in diabetes mellitus in which very marked hyperglycaemia occurs (such as levels over 800 mg/dL) causing osmotic shifts in water in brain cells and resulting in coma. It can be fatal or lead to permanent neurologic damage. Ketoacidosis does not occur in these cases. Synonym: nonketotic hyperglycaemia. (05 Mar 2000)