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Medical Definition of Hyperacute rejection
1. A rejection that usually develops in less than one hour from the implantation of a vascular graft, a form of antibody-mediated, usually irreversible damage to a transplanted organ, particularly the kidney, manifested predominantly by diffuse thrombotic lesions, usually confined to the organ itself and only rarely disseminated, for skin allograft rejection of this type, see white graft. (05 Mar 2000)