Lexic.us

Definition of Histone

1. Noun. A simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids.

Definition of Histone

1. Noun. (biochemistry) Any of various simple water soluble proteins that are rich in the basic amino acids lysine and arginine and are complexed with DNA in the nucleosomes of eukaryotic chromatin. ¹

¹ Source: wiktionary.com

Definition of Histone

1. a simple protein [n -S]

Medical Definition of Histone

1. Protein found in the nuclei of all eukaryotic cells where they are complexed to DNA in chromatin and chromosomes. They are of relatively low molecular weight and are basic, having a very high arginine/lysine content. They are highly conserved and can be grouped into five major classes. Two copies of H2A, H2B, H3 and H4 bind to about 200 base pairs of DNA to form the repeating structure of chromatin, the nucleosome, with H1 binding to the linker sequence. They may act as non-specific repressors of gene transcription. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Histone

Literary usage of Histone

Below you will find example usage of this term as found in modern and/or classical literature:

1. Elements of the Comparative Anatomy of Vertebrates by Gustav Mann, Walther Löb, Henry William Frederic Lorenz, Robert Wiedersheim, William Newton Parker, Thomas Jeffery Parker, Harry Clary Jones, Sunao Tawara, Leverett White Brownell, Max Julius Louis Le Blanc, Willis Rodney Whitney, John Wesley Brown, Wi (1906)
"According to Bang, thymus-histone forms with HC1 two kinds of salts, namely, ... The 6 valencies of the histone, satisfied by the 6 Cl in the neutral salt, ..."

2. Chemistry of the Proteids by Gustav Mann (1906)
"According to Bang, thymus-histone forms with HC1 two kinds of salts, namely, a neutral salt containing 6 Cl, and an acid salt with 13 CI. ..."

3. Mammalian Embryo Genomics by Oecd, (Paris) Organisation for Economic Co-ope, OECD Staff (2003)
"Quantification of histone Acetyltransferases Transcripts in the Early Stages of Bovine Embryo Development S. McGraw, C. Robert, L. Massicotte, and MA Sirard ..."

4. A Text-book of Physiological Chemistry by Olof Hammarsten, Sven Gustaf Hedin (1914)
"As a second cleavage product it yields, according to MALENGREAU, the A-histone, which can be readily precipitated by magnesium and ammonium sulphates from ..."

5. Gene Expression in Field Crops: Bibliography January 1991-November 1992 edited by Janet Saunders, Robert D. Warmbrodt (1995)
"51 NAL Call No: 450 P692 Differential expression of histone H3 gene variants during cell cycle and somatic embryogenesis in alfalfa. Kapros, T.; Bogre, L.; ..."

6. Physiological chemistry: A Text-book and Manual for Students by Albert Prescott Mathews (1916)
"It is impossible to extract all the protein from the nuclei of all cells by acid. The union is too firm. Other basic constituents. histone. ..."

7. The History and Description of Africa: And of the Notable Things Therein by Robert Brown, John Pory, Leo (1896)
"... IOHN LEO HIS NINTH BOOKE OF the histone of Africa, and of the memorable things therein contained. ..."

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