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Medical Definition of Hepatic lobule
1. The conceptual polygonal histologic unit of the liver consisting of masses of liver cells arranged around a central vein, a terminal branch of one of the hepatic veins; at the periphery are located preterminal and terminal branches of the portal vein, hepatic artery, and bile duct, hepatic lobules have anatomical reality in the pig liver or pathologically in humans, when fibrous septa are present. Synonym: lobulus hepatis. (05 Mar 2000)