Medical Definition of Heavy chain disease

1. A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the n- (amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (v) and constant (c) region genes. (12 Dec 1998)

Lexicographical Neighbors of Heavy Chain Disease

heavy(a)
heavy(p)
heavy-armed
heavy-coated
heavy-duty
heavy-footed
heavy-handed
heavy-laden
heavyhearted
heavyheartedly
heavyheartedness
heavyset
heavyweight
heavyweights
heavy chain
heavy chain disease (current term)
heavy cream
heavy hitter
heavy hydrogen
heavy hydrogen
Heavy Ion Beams
heavy lifting
heavy liquid petrolatum
heavy metal
heavy metal
heavy metal neuropathy
heavy nitrogen
heavy oxygen
heavy particle
heavy spar

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