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Medical Definition of Glycine cleavage complex
1. A complex of several proteins that catalyze the reversible reaction of glycine with tetrahydrofolate to produce CO2, NH3, and N5,N10-methylenetetrahydrofolate; a deficiency of this enzyme (or one of its subunits) will result in nonketotic hyperglycinaemia. Synonym: glycine synthase. (05 Mar 2000)