Lexic.us

Definition of Glyceryl trinitrate

1. Noun. A heavy yellow poisonous oily explosive liquid obtained by nitrating glycerol; used in making explosives and medically as a vasodilator (trade names Nitrospan and Nitrostat).

Medical Definition of Glyceryl trinitrate

1. A liquid appearing like a heavy oil, colourless or yellowish, and consisting of a mixture of several glycerin salts of nitric acid, and hence more properly called glycerin nitrate. It is made by the action of nitric acid on glycerin in the presence of sulphuric acid. It is extremely unstable and terribly explosive. A very dilute solution is used in medicine as a neurotic under the name of glonion. A great number of explosive compounds have been produced by mixing nitroglycerin with different substances; as, dynamite, or giant powder, nitroglycerin mixed with siliceous earth; lithofracteur, nitroglycerin with gunpowder, or with sawdust and nitrate of sodium or barium; Colonia powder, gunpowder with nitroglycerin; dualin, nitroglycerin with sawdust, or with sawdust and nitrate of potassium and some other substances; lignose, wood fibre and nitroglycerin. Pharmacologic action: Relaxes smooth muscle - dilates veins, dilates coronary arteries, reduces left ventricular filling pressure, lowers systemic vascular resistance, decreases myocardial oxygen demand. Uses: Treat angina pectoris. Dose: One tablet (0.3 to 0.4 mg) sublingual, may repeat twice at 5 minute intervals Intravenous infusion: 0.5 - 2 mcg/kg per min. Potential complications: May cause hypotension, especially if hypovolemic; headache is common. Alternative forms: nitroglycerine. Origin: Nitro- + glycerinn. (17 Mar 2000)

Lexicographical Neighbors of Glyceryl Trinitrate

Literary usage of Glyceryl trinitrate

Below you will find example usage of this term as found in modern and/or classical literature:

1. A Treatise on Pharmacy for Students and Pharmacists by Charles Caspari, Evander Francis Kelly (1920)
"In the form of a 1 per cent, alcoholic solution glyceryl trinitrate is ... Gm. (yf^ and ^V grain) of glyceryl trinitrate each are also used by physicians; ..."

2. Materia Medica and Therapeutics: Including Pharmacy and Pharmacology by Reynold Webb Wilcox (1917)
"ACTION OF glyceryl trinitrate The spirit of glyceryl trinitrate is at first sweetish to the taste, ..."

3. The Pharmacopeia and the physician: A Series of Articles which Originally by Robert Anthony Hatcher, Martin I. Wilbert (1908)
"The effects of glyceryl trinitrate or ni trog] y- eerin are much more slowly ... glyceryl trinitrate is not decomposed in the stomach, but it has the ..."

4. The Pharmacopeia and the Physician: A Series of Articles which Originally by Robert Anthony Hatcher, Martin Inventius Wilbert (1908)
"Amyl nitrite acts very rapidly when inhaled, but the action is over in about twenty minutes. The effects of glyceryl trinitrate or ..."

5. Manual of Chemistry: A Guide to Lectures and Laboratory Work for Beginners by William Simon (1916)
"Spirit of glyceryl trinitrate is an alcoholic solution of nitro-glycerin, containing 1 per cent, of this substance. Dynamite.—One kilogram of nitro-glycerin ..."

6. Materia Medica and Therapeutics, Including Pharmacy and Pharmacology by Reynold Webb Wilcox (1917)
"glyceryl trinitrate For the Preparations of glyceryl trinitrate see p. 104. ACTION OF glyceryl trinitrate The spirit of glyceryl trinitrate is at first ..."

7. Principles of Pharmacy by Henry Vinecome Arny (1917)
"Spirit of glyceryl trinitrate. Spirit of juniper. Spirit of juniper, compound. Spirit of nitrous ether. Spirit of lavender. Spirit of orange, compound. ..."

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