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Definition of Give up the ghost
1. Verb. (intransitive idiomatic) To cease clinging to life; to die. ¹
2. Verb. (intransitive idiomatic figuratively) To quit; to cease functioning. ¹
3. Verb. (intransitive with ''of'') To cede a commitment to or identification with. ¹
¹ Source: wiktionary.com