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Medical Definition of Fly blister
1. A cantharidal blister caused by discharge of a vesicating body fluid by certain beetles, particularly members of the family Meloidae which produce cantharidin, e.g., Lytta (Cantharis) vesicatoria, the notorious "Spanish fly;" non-cantharidin vesicating fluid is produced by other beetles, such as rove beetles (family Staphylinidae), especially the genus Paederus, whose fluid, on contact with the skin, produces an intensely painful blister. (05 Mar 2000)