Medical Definition of Fibulin
1.
Calcium binding, cysteine rich glycoprotein found in the extracellular matrix and in plasma.
Alternative splicing generates three forms of fibulin with 566, 601 and 683 amino acids respectively. All three forms have three repeated motifs near the N terminus, with the bulk of the remaining chain formed of nine EGF like repeats.
Fibulin was originally described as a cytoplasmic protein, but this identification was based on fortuitous binding to the integrin _1 subunit.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(22 Feb 2008)
Lexicographical Neighbors of Fibulin
Other Resources:
