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Medical Definition of Fibrous plaque
1. Thickened area of arterial intima with accumulation of smooth muscle cells and fibrous tissue (collagen etc.) produced by the fat laden smooth muscle cells. Below the thickening may be free extracellular lipid and debris that, if much necrosis is also present, is referred to as an atheroma. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)