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Medical Definition of Esthesioneuroblastoma
1. A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumours) and its aetiology is unknown. The type and extent of primary therapy depends on tumour size and location. Generally early-stage disease is treated with a single modality approach such as complete excision. Adjuvant radiotherapy is used for extensive tumours or for tumours where microscopic residual disease is suspected. It has a high propensity for multiple local recurrences. (holland et al., cancer medicine, 3d ed, p1245) (12 Dec 1998)