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Medical Definition of Electron microprobe
1. A technique of elemental analysis in the electron microscope based on spectral analysis of the scattered X-ray emission from the specimen induced by the electron beam. Using this technique it is possible to obtain quantitative data on, for example: the calcium concentration in different parts of a cell, but it is necessary to use ultra thin frozen sections. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)