Medical Definition of Eflornithine
1.
2-(difluoromethyl)-dl-ornithine. An inhibitor of ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthetic pathway. As a result of this inhibition of polyamine synthesis, the compound is effective in preventing cancer formation in many organ systems, inhibiting cancer growth, and reducing tumour size. It also has synergistic action with other antineoplastic agent. In addition, it has been found effective as a trypanocidal agent.
Pharmacological action: antineoplastic agent, enzyme inhibitors, trypanocidal agents.
Chemical name: Ornithine, 2-(difluoromethyl)-
(12 Dec 1998)
Lexicographical Neighbors of Eflornithine
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