Lexic.us

Definition of Dopamine

1. Noun. A monoamine neurotransmitter found in the brain and essential for the normal functioning of the central nervous system; as a drug (trade names Dopastat and Intropin) it is used to treat shock and hypotension.

Definition of Dopamine

1. Noun. (neurotransmitter) A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system. ¹

¹ Source: wiktionary.com

Definition of Dopamine

1. a form of dopa used to stimulate the heart [n -S]

Medical Definition of Dopamine

1. A catecholamine neurotransmitter and hormone (153 D), formed by decarboxylation of dehydroxyphenylalanine (dopa). A precursor of adrenaline and noradrenaline. Pharmacologic action: 1. Precursor of norepinephrine 2. Stimulates dopaminergic, alpha and beta-1 adrenergic receptors: 3. Dopaminergic (1-2 mcg/kg per min): cerebral, renal, and mesenteric vasodilation increase urine output 4. Mixed alpha and beta-1 (2-10 mcg/kg per min): increases cardiac ouput with moderate increase systemic vascular resistance 5. Predominantly alpha (>20 mcg/kg per min): increases systemic vascular resistance Uses: 1. Treat hypotension associated with bradycardia 2. Stimulate cardiac output and urine output Dose: 1. Start infusion at 1-5 mcg/kg per min and titrate to effect. 2. Use the lowest dose that provides the desired hemodynamic improvement. 3. Do not exceed 20 mcg/kg per min. Potential complications: 1. May increase pulmonary pressure and worsen pulmonary congestion. 2. May increase myocardial work without improving coronary blood flow, exacerbating myocardial ischemia 3. Stimulates heart rate and may cause supraventricular or ventricular arrhythmias (15 Mar 2000)

Lexicographical Neighbors of Dopamine

Literary usage of Dopamine

Below you will find example usage of this term as found in modern and/or classical literature:

1. Science by American Association for the Advancement of Science (1883)
"Drugs (dopamine hydrochloride and amantadine hydro- chloride) were rapidly injected through a polyethylene cannula in the femoral vein in aqueous solutions ..."

2. Stress, Gender, and Alcohol-Seeking Behavior edited by Walter A. Hunt, Sam Zakhari (1996)
"Both of these possibilities However, these dopamine terminal have been examined ... Consistent with for elevating dopamine transmission this difference, ..."

3. Proceedings of the Society for Experimental Biology and Medicine (1903)
"dopamine (Sigma) solutions, prepared in 0.1% ascorbic acid (Sigma) to prevent oxidation, were added to the slice preparation before the 1-hr incubation ..."

4. Molecular Neurobiology: Proceedings of the Second Nimh Conference by Steven Zalcman (1995)
"Interestingly, chronic dopamine depletion with reserpine did not affect mRNA ... Receptor blockade by antagonists, denervation or depletion of dopamine by ..."

5. Treatment for Stimulant Use Disorders edited by Richard A. Rawson, Rose M. Urban (2000)
"As a CNS stimulant, cocaine affects a number of neurotransmitter systems, but it is through its interaction with the dopamine and the limbic reward system ..."

6. A Lifelong Passion: Nicholas and Alexandra: Their Own Story by Andrei Maylunas (2005)
"BM Nicotine indirectly inhibits (3H)dopamine uptake at concentrations that do not directly promote (3H)dopamine release in rat striatum. ..."

7. Cocaine: Pharmacology, Effects, and Treatment of Abuse edited by John Grabowski (1994)
"With high doses of dopamine antagonists it appears that the reinforcing efficacy of amphetamine and cocaine is either eliminated or reduced to levels ..."

8. Risk Assessment for Neurobehavioral Toxicity edited by Bernard Weiss, Jurg Elsner (1997)
"(C) Monkey caudate nucleus dopamine. Data from Slikker and Gaylor ( 77). be ... The two-parameter probit model fits with observed reductions in dopamine ..."

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