Medical Definition of Disintegrins
1.
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (rgd) sequence. The rgd tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Pharmacological action: platelet aggregation inhibitors.
(12 Dec 1998)
Lexicographical Neighbors of Disintegrins
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