1. A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (rgd) sequence. The rgd tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Pharmacological action: platelet aggregation inhibitors.
(12 Dec 1998)
