Definition of Dielectrolysis
1. Noun. The motion of charged particles in a colloid under the influence of an electric field; particles with a positive charge go to the cathode and negative to the anode.
Medical Definition of Dielectrolysis
1.
Separation of ionic molecules, (principally proteins) by the differential migration through a gel according to the size and ionic charge of the molecules in an electrical field. High resolution techniques normally use a gel support for the fluid phase.
Examples of gels used are starch, acrylamide, agarose or mixtures of acrylamide and agarose. Frictional resistance produced by the support causes size, rather than charge alone, to become the major determinant of separation.
Smaller molecules with a more negative charge will travel faster and further through the gel toward the anode of an electrophoretic cell when high voltage is applied. Similar molecules will group on the gel. They may be visualised by staining and quantitated, in relative terms, using densitometers which continuously monitor the photometric density of the resulting stain.
The electrolyte may be continuous (a single buffer) or discontinuous, where a sample is stacked by means of a buffer discontinuity, before it enters the running gel/ running buffer. The gel may be a single concentration or gradient in which pore size decreases with migration distance.
In SDS gel electrophoresis of proteins or electrophoresis of polynucleotides, mobility depends primarily on size and is used to determined molecular weight. In pulse field electrophoresis, two fields are applied alternately at right angles to each other to minimise diffusion mediated spread of large linear polymers.
See: electrofocussing, pulse field electrophoresis
(01 Dec 1998)
Lexicographical Neighbors of Dielectrolysis
Literary usage of Dielectrolysis
Below you will find example usage of this term as found in modern and/or classical literature:
1. Quarterly Compendium of Medical Science by D. G. Brinton (1887)
"Brondel may have failed, but there is a therapeutic power in dielectrolysis of
which we have now partial confirmation, advantage of which will be taken by ..."
2. The Year-book of Treatment (1886)
"A new therapeutic method: dielectrolysis. Dr. A. Brondel, at a Meeting of the
Academy of Medicine (Paris, September 22), read a communication with regard to ..."
3. Veterinary Medicines by Finlay Dun (1911)
"... with the assistance of an electric current (cataphoresis and dielectrolysis),
but absorption readily occurs from open wounds and abraded skin surfaces. ..."
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