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Medical Definition of Crush syndrome
1. Trauma and ischemia of soft tissues, principally skeletal muscle, due to prolonged severe crushing of the tissues, leading to increased permeability of the cell membrane and to the release of potassium, enzymes, and myoglobin from within cells. Ischemic renal dysfunction secondary to hypotension and diminished renal perfusion results in acute tubular necrosis and uraemia. (12 Dec 1998)