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Medical Definition of Crus cerebri
1. Specifically, the massive bundle of corticofugal nerve fibres passing longitudinally on the ventral surface of the midbrain on each side of the midline; it consists of fibres descending from the cortex to the tegmentum of the brainstem, pontine gray matter, and spinal cord. See: cerebral peduncle, basis pedunculi. (05 Mar 2000)