Lexic.us

Definition of Colchicine

1. Noun. An analgesic drug derived from the saffron plant and used to treat gout.

Definition of Colchicine

1. n. A powerful vegetable alkaloid, C₁₇H₁₉NO₅, extracted from the Colchicum autumnale, or meadow saffron, as a white or yellowish amorphous powder, with a harsh, bitter taste; -- called also colchicia.

Definition of Colchicine

1. Noun. A highly toxic alkaloid, chemical formula C₂₂H₂₅NO₆, originally extracted from plants of the genus ''Colchicum'' and formerly used to treat rheumatic complaints, now used mainly in the treatment of gout. ¹

¹ Source: wiktionary.com

Definition of Colchicine

1. [n -S]

Medical Definition of Colchicine

1. Alkaloid (400 D) isolated from the Autumn crocus (Colchicum autumnale) that blocks microtubule assembly by binding to the tubulin heterodimer (but not to tubulin). As a result of interfering with microtubule reassembly will block mitosis at metaphase. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Colchicine

Literary usage of Colchicine

Below you will find example usage of this term as found in modern and/or classical literature:

1. A Textbook of pharmacology and therapeutics, or, the Action of drugs in by Arthur Robertson Cushny (1918)
"Large doses, corresponding to 4-5 mgs. of colchicine, cause diarrhoea with some ... In poisoning with colchicine, whether given by the mouth or injected ..."

2. Science by American Association for the Advancement of Science (1883)
"ing colchicine to hexaploid wheat which possessed an isochromosome. ... Thus, in the case of colchicine-treated material, being attached to a common ..."

3. Hand-book of Chemistry by Leopold Gmelin, Henry Watts (1866)
"colchicine burns with a smoky flame on platinum-foil, puffing- up and leaving a bulky ... Chlorine-water produces in aqueous colchicine a slight yellow ..."

4. A Text-book of Alkaloidal Therapeutics by William Francis Waugh, Wallace C. Abbott, Ephraim Menahhem Epstein (1904)
"colchicine is the active principle of Colchicum autumnale, ... It is doubtful if colchicine ranks with the alkaloids, as a pyridine derivative, ..."

5. Proceedings of the American Pharmaceutical Association at the Annual Meeting by American Pharmaceutical Association, National Pharmaceutical Convention, American Pharmaceutical Association Meeting (1867)
"ON colchicine. BY C. LEWIS DIEHL. There exist perhaps few vegetable proximate ... colchicine from root. As a preliminary to my experiments on the seeds, ..."

6. Poisons: Their Effects and Detection by Alexander Wynter Blyth, Meredith Wynter Blyth (1906)
"colchicine (C^H.^NO,.) may be extracted from the seeds, etc., in the manner ... colchicine is now precipitated as a tannate.* The precipitation is best ..."

7. American Druggist (1890)
"Dr. Bischoff now repeated his analysis, and reasserted the presence of colchicine in the liquid, stating that it corresponded in quantity to that contained ..."

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