Medical Definition of Caldesmon

1. Protein originally isolated from smooth muscle (h caldesmon, 120-150 kD on gels but 88.7 kD from sequence) also found in nonmuscle cells (l caldesmon, 70-80 kD on gels but 58.8 kD from sequence). Normally dimeric, binds to F actin blocking the myosin binding site. Calcium calmodulin binding to caldesmon causes its release from actin, though phosphorylation of caldesmon may also affect the link with actin. Caldesmon can block the effect of gelsolin on f actin and will dissociate actin gelsolin complexes and actin profilin complexes. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Caldesmon

calculus II
calculus of variations
Calculus Surface Index
Calcutta
Calcuttan
calcyclin
calcyphosin
Caldani's ligament
caldaria
caldarium
Calder
caldera
calderas
Calderon
Calderon de la Barca
caldesmon (current term)
caldolase
caldron
caldrons
Caldwell
Caldwell-Luc operation
Caldwell-Moloy classification
Caldwell projection
Caldwell view
calean
caleche
caleches
Caledonia
Caledonian Canal
calefacient

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