Medical Definition of Buthionine sulfoximine
1.
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation.
Pharmacological action: antimetabolites, antimetabolites, antineoplastic, enzyme inhibitors, radiation-protective agents, radiation-sensitizing agents.
Chemical name: Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
(12 Dec 1998)
Lexicographical Neighbors of Buthionine Sulfoximine
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