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Medical Definition of Benign giant lymph node hyperplasia
1. Solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma. Synonym: angiofollicular mediastinal lymph node hyperplasia, Castleman's disease. (05 Mar 2000)