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Medical Definition of Autoagglutinin
1. An agglutinating autoantibody. Anti-Pr cold autoagglutinin, a cold autoagglutinin specific for the Pr (protease-sensitive) antigen of erythrocytes. Cold autoagglutinin, a heterogeneous group of autoantibodies that react at temperatures below 37°C, often most actively at 4°C; most are the IgM class of immunoglobulins with affinity for the Ii system of erythrocyte antigens, but some are anti-Pr cold autoagglutinin's; cold autoagglutinin's may be associated with infection (e.g., primary atypical pneumonia, infectious mononucleosis and other virus infections, certain protozoan infections) and in such instances usually are not active in vivo. (05 Mar 2000)