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Medical Definition of Y-linkage
1. The state of a genetic factor (gene) being borne on the Y chromosome. This idea is analogous with X-linkage but since the Y chromosome does not fully take part in chiasma formation and recombination, it not amenable to analysis by conventional linkage methods. Little is known about its content. There is a gene for the H-Y antigen, and indirect arguments suggest that there is a principle that determines the formation of the testis and masculinization of the foetus but its localization, though narrowing the limits, remains elusive. (05 Mar 2000)