Lexic.us

Definition of Tay-Sachs disease

1. Noun. A hereditary disorder of lipid metabolism occurring most frequently in individuals of Jewish descent in eastern Europe; accumulation of lipids in nervous tissue results in death in early childhood.

Medical Definition of Tay-Sachs disease

1. A genetic disorder found in east European Jewish families which can result in early death bu affecting the brain and nerves by causing abnormal lipid metabolism. It is a lysosomal disease in which there is a deficiency of hexosaminidase A, an enzyme that degrades ganglioside GM2. Symptoms appear at age 3-6 months and include blindness, deafness, seizures, paralysis, dementia, decreased muscle tone and growth retardation. There is no known treatment and most children usually die between 2 and 5 years of age. Inheritance: autosomal recessive. (06 Oct 1997)

Lexicographical Neighbors of Tay-Sachs Disease

Literary usage of Tay-Sachs disease

Below you will find example usage of this term as found in modern and/or classical literature:

1. Genetic Tests and Health Insurance: Results of a Survey (1993)
"Tay-Sachs disease: A lethal, recessive disorder affecting the central nervous ... Tay-Sachs disease predominantly occurs among Jews of Eastern and Central ..."

2. Genes, Behavior, and the Social Environment: Moving Beyond the Nature by Lyla M. Hernandez, Dan G. Blazer (2006)
"... certain forms of cancer, such as breast and colon cancer (McClain et al., 2005). Screening for carriers of Tay-Sachs disease has virtually eliminated ..."

3. Nervous and Mental Disease Monograph Series (1907)
"The two cases reported by Gordon "are allied to the Tay-Sachs disease first, because the blindness with which they are afflicted was noticed very early in ..."

4. An Introduction to the History of Medicine by Fielding Hudson Garrison (1914)
"... the ocular manifestations of which had been noted in 1880 by Waren Tay (Tay-Sachs disease) ; William F. Milroy, of Omaha, Nebraska, described persistent ..."

5. An Introduction to the History of Medicine by Fielding Hudson Garrison (1913)
"... the ocular manifestations of which had been noted in 1880 by Waren Tay (Tay-Sachs disease); William F. Milroy, of Omaha, Nebraska, described persistent ..."

6. The Diseases of Children: A Work for the Practising Physician by Meinhard von Pfaundler, Arthur Schlossmann, Henry Larned Keith Shaw, Linnæus Edford La Fétra, Luther Emmett Holt (1912)
"... received the name of Tay-Sachs disease. Amaurotic family idiocy is usually observed in several children of the same family, although a number of ..."

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