Medical Definition of TGF

1. Proteins secreted by transformed cells that can stimulate growth of normal cells. Unfortunate misnomer, since they induce aspects of transformed phenotype, such as growth in semi solid agar, but do not actually transform. Transforming growth factor alpha, 50 amino acid polypeptide originally isolated from viral transformed rodent cells, contains EGF like domain and binds to EGF receptor. Stimulates growth of microvascular endothelial cells, i.e. Is angiogenic. Transforming growth factor beta a homodimer of two 112 chains, polypeptide is secreted by many different cell types, stimulates wound healing but in vitro is also a growth inhibitor for certain cell types. The transforming growth factor family includes many of the bone morphogenetic proteins. Acronym: TGF This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of TGF

TEU
TEUs
TEWT
TF-IDF
TFA
TFN
TFS
TFT
TFTP
TG
TG-girl
TGA
TGC
TGE
TGE virus
TGF (current term)
TGF-beta receptor protein kinase
TGFa
TGFb
TGIF
TGV
TGVs
THAAD
THAM
THC
THCV
THF
THG

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