Medical Definition of PDGF

1. The major mitogen in serum for growth in culture of cells of connective tissue origin. It consists of 2 different but homologous polypeptides A and B (~30,000 D) linked by disulphide bonds. Believed to play a role in wound healing. It is carried in the alpha-granules of platelets and is released when platelets adhere to traumatised tissues. Connective tissue cells near the traumatised region respond by initiating the process of replication. The B chain is almost identical in sequence to p28sis, the transforming protein of simian sarcoma virus, that can transform only those cells that express receptors for platelet derived growth factor, suggesting that transformation is caused by autocrine stimulation. The receptor is a tyrosine kinase. Acronym: PDGF (12 Dec 1998)

Lexicographical Neighbors of PDGF

PCP
PCR
PCR test
PCT
pct
PCTAIRE-2 protein kinase
PCWP
PC board
Pd
Pd
PDA
PDA
PDD
PDE4D3 phosphodiesterase
PDFLP
PDGF (current term)
PDI
PDL
pdl
PDLL
PDQ
PDR
pe
pe-tsai
pea
pea
pea-chick
pea-green
pea-souper
peaberry

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