Medical Definition of Gerstmann-Straussler-Scheinker syndrome

1. A familial spongiform encephalopathy. Transgenic mice with a mutant form of the PrP gene from patients with this syndrome develop degenerative brain disease that is similar, but not identical, to that caused by scrapie. It is a more chronic cerebellar form of spongiform encephalopathy, producing a neurodegenerative condition that has morphological similarities to Creutzfeldt-Jakob syndrome. However, in this syndrome there is slower progression, signs of spinocerebellar ataxia, and the spongiosis is less pronounced. Prion proteins and amyloid plaques are found in the brain of patients with the syndrome. A germline mutation of the prion protein has been demonstrated. (12 Jul 2000)

Lexicographical Neighbors of Gerstmann-Straussler-Scheinker Syndrome

Gerota's fascia
Gerota's method
Gerreidae
Gerres
Gerres cinereus
Gerrhonotus
Gerridae
Gerrididae
Gerris
Gerris lacustris
gerrymander
gerrymandered
gerrymandering
gerrymanders
Gershwin
Gerstmann-Straussler-Scheinker syndrome (current term)
Gerstmann syndrome
gert
gertcha
Gertrude Caroline Ederle
Gertrude Ederle
Gertrude Lawrence
Gertrude Stein
gerund
gerundial
gerundive
gerundives
gerunds
Geryon
Gesell

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