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Medical Definition of Gaucher cells
1. Large, finely and uniformly vacuolated cell's derived from the reticuloendothelial system, and found especially in the spleen, lymph nodes, liver, and bone marrow of patients with Gaucher's disease; Gaucher cell's contain kerasin (a cerebroside), which accumulates as a result of a genetically determined absence of the enzyme glucosylceramidase. (05 Mar 2000)