Medical Definition of G-protein coupled receptor
1.
| Cell surface receptors that are coupled to G-proteins (GTP-binding protein).
G-protein coupled receptors are thought to have seven membrane spanning domains and have been divided into 2 subclasses: those in which the binding site is in the extracellular domain for example receptors for glycoprotein hormones, such as thyroid stimulating hormone (TSH) and follicle-stimulating hormone (FSH) and those in which the ligand binding site is likely to be in the plane of the 7 transmembrane domains for example rhodopsin and receptors for small neurotransmitters and hormones for example muscarinic acetylcholine receptor.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
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Lexicographical Neighbors of G-protein Coupled Receptor
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