Medical Definition of DNA topoisomerase
1.
An enzyme capable of altering the degree of supercoiling of double stranded DNA molecules. Various topoisomerases can increase or relax supercoiling, convert single stranded rings to intertwined double stranded rings, tie and untie knots in single stranded and duplex rings, catenate and decatenate duplex rings. Topoisomerase II of E. Coli = gyrase.
This entry appears with permission from the Dictionary of Cell and Molecular Biology
(11 Mar 2008)
Lexicographical Neighbors of DNA Topoisomerase
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