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Medical Definition of ALT:AST ratio
1. The ratio of serum alanine aminotransferase to serum aspartate aminotransferase; elevated serum levels of both enzymes characterise hepatic disease; when both levels are abnormally elevated and the ALT:AST ratio is greater than 1.0, severe hepatic necrosis or alcoholic hepatic disease is likely; when the ratio is less than 1.0, an acute non-alcoholic hepatic condition is favoured. (05 Mar 2000)