Lexic.us

Definition of Tumor necrosis factor

1. Noun. A proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis).

Definition of Tumor necrosis factor

1. Noun. (medicine) Any of several polypeptide hormones, produced by macrophages, that can destroy some cancer cells ¹

¹ Source: wiktionary.com

Medical Definition of Tumor necrosis factor

1. Originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette-Guerin. Preferentially kills tumour cells in vivo and in vitro, causes necrosis of certain transplanted tumours in mice and inhibits experimental metastases. Human Tumour Necrosis factor alpha is a protein of 157 amino acids and has a wide range of pro inflammatory actions. Usually considered a cytokine. Synonym: cachectin. Acronym: TNF (13 Nov 1997)

Lexicographical Neighbors of Tumor Necrosis Factor

Literary usage of Tumor necrosis factor

Below you will find example usage of this term as found in modern and/or classical literature:

1. Oxygen/Nitrogen Radicals and Cellular Injury edited by Kenneth B. Adler, Robert D. Devlin, Val Vallyathan (2000)
"tumor necrosis factor alpha (TNF(x)-induced ICAM-1 surface expression in airway epithelial cells in vitro: possible signal transduc- 38. tion mechanisms. ..."

2. Alternative Medicine: Expanding Medical Horizons by DIANE Publishing Company (1995)
"Endotoxin-induced tumor necrosis factor. Recent Results Cancer Res. 75:207-212. ... tumor necrosis factor. Another chapter in the long history of endotoxin. ..."

3. Children's Environmental Health Research: Indoor Mold and Children's Health edited by Allen Dearry, Gwen Collman (2000)
"Neutralization of IL-10 increases lethality ¡n endotoxemia: cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. ..."

4. The Neuroscience of Mental Health: A Report on Neuroscience Research edited by Stephen H. Koslow (1997)
"These astrocytes, when stimulated, express MHC class-II antigens and produce a wide array of cytokines, including interleukin-1, tumor necrosis factor, ..."

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