Medical Definition of Tissue inhibitor-of metalloproteinase-2

1. A member of the family of tissue inhibitor of metalloproteinases. It is a 21 kD nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase a by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of timp-2 has been shown to inhibit invasive and metastatic activity of tumour cells and decrease tumour growth in vivo. Pharmacological action: antineoplastic agent, protease inhibitors. (12 Dec 1998)



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Lexicographical Neighbors of Tissue Inhibitor-of Metalloproteinase-2

tissue culture infectious dose
tissue culture plastic
tissue displaceability
tissue displacement
tissue distribution
tissue donors
tissue embedding
tissue engineering
tissue expanders
tissue expansion
tissue extracts
tissue factor
tissue fixation
tissue fluid
tissue hormones
tissue inhibitor-of metalloproteinase-2 (current term)
tissue inhibitor of-metalloproteinase-3
tissue inhibitor of metalloproteinases
tissue inhibitors of metalloproteinase
tissue layer
tissue lymph
tissue molding
tissue paper
tissue perfusion
tissue plasminogen activator
tissue polypeptide antigen
tissue preservation
tissue procollagenase
tissue registration
tissue respiration

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