Definition of Thiotepa

1. Noun. An antineoplastic drug used to treat certain malignancies.


Definition of Thiotepa

1. Noun. A particular drug used in chemotherapy. ¹

2. Noun. A particular drug used in chemotherapy. ¹

¹ Source: wiktionary.com

Definition of Thiotepa

1. a chemical compound [n -S]

Medical Definition of Thiotepa

1. A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the fourth annual report on carcinogens (ntp 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (merck index, 11th ed). Pharmacological action: alkylating agents, antineoplastic agent, alkylating, carcinogens, chemosterilants. Chemical name: Aziridine, 1,1',1''-phosphinothioylidynetris- (12 Dec 1998)

Lexicographical Neighbors of Thiotepa

thiosulfate cyanide transsulfurase
thiosulfate reductase
thiosulfate sulfurtransferase
thiosulfate thiotransferase
thiosulfates
thiosulfonate
thiosulfonates
thiosulfonic acid
thiosulfonic acids
thiosulfuric
thiosulfuric acid
thiosulphate
thiosulphates
thiosulphuric
thiosulphuric acid
thiotepa (current term)
thiotepas
thiothixene
thiothixenes
thiotolene
thiotolenes
thiotoluene
thiotoluenes
thiotransacetylase B
thiotriphosphate
thiotriphosphates
thiotroph
thiotrophic
thiotrophs
thiouracil

Literary usage of Thiotepa

Below you will find example usage of this term as found in modern and/or classical literature:

1. Eighth Annual Report on Carcinogens: 1998 Summary edited by Barry Leonard (1999)
"thiotepa is carcinogenic at multiple sites in both sexes of mice and rats. In mice, thiotepa administered by intraperitoneal (ip) injection induced lymphoma ..."

2. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"thiotepa is mutagenic and carcinogenic not only in rodents (41,42) but also in ... thiotepa has been reported to induce lymphoma, lymphocytic leukemia, ..."

3. Mammalian Models for Research on Aging by Institute Of Laboratory Animal Resources, Bennett J. Cohen, National Research Council Staff (1981)
"thiotepa and BUdR in particular produce cataracts with few side effects. Bilateral, congenital, nuclear cataracts develop between the sixteenth and ..."

4. Sas/stat 9.1 User's Guide by SAS Institute, Virginia Clark (2004)
"Of these patients, 48 were randomized into the placebo group, and 38 were randomized into the thiotepa group. Many patients had multiple recurrences of ..."

5. Implementing Cancer Survivorship Care Planning: Workshop Summary by Maria Elizabeth Hewitt, Patricia Ganz (2007)
"... (continued) Procarbazine Temozolomide Teniposide (VM-26) Thioguanine (6-TG) thiotepa Topotecan Trimetrexate Vinorelbine Vinblastine Vincristine Other, ..."

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