Lexic.us

Definition of Telomerase

1. Noun. An enzyme in eukaryotic cells that can add telomeres to the ends of chromosomes after they divide.

Definition of Telomerase

1. Noun. (context: enzyme genetics) An enzyme in eukaryotic cells that adds a specific sequence of DNA to the telomeres of chromosomes after they divide; gives the chromosomes stability over time. ¹

¹ Source: wiktionary.com

Medical Definition of Telomerase

1. A DNA polymerase with rather unusual properties that will only elongate oligonucleotides from the telomere and not other sequences. The enzyme contains an essential 159 residue RNA sequence that provides a template for the replication of the G rich telomere sequences (so that the enzyme could in fact be considered a reverse transcriptase). This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Telomerase

Literary usage of Telomerase

Below you will find example usage of this term as found in modern and/or classical literature:

1. Genomic Signal Processing and Statistics by Edward R Dougherty (2005)
"(1) telomerase as a target for cancer therapy. telomerase is a special enzyme that is expressed in most cancer and immortal cells [50]. ..."

2. Mammalian Embryo Genomics by OECD Staff, Oecd, (Paris) Organisation for Economic Co-ope (2003)
"Betts D, Bordignon V, Hill J, Winger Q, Westhusin M, Smith L, and King W. (2001), Reprogramming of telomerase activity and rebuilding of telomere length in ..."

3. Asbestos: Selected Cancers by Institute of Medicine (U. S.) (2006)
"... thereby inducing genetic and karyotypic instability (White et al. 2005). SV40 virus also induces telomerase activity and immortalization of human me- ..."

4. Catalyzing Inquiry at the Interface of Computing and Biology by John C. Wooley, Herbert Lin (2005)
"Among the potential targets assessed to date are oncogenes, tumor-suppressor genes, drug resistance-mediating transporters, heat shock proteins, telomerase, ..."

5. Biotechnology: Ti-Plasmids and Other Plan Vectors: Bibliography January 1993 by Raymond Dobert (1996)
"... telomeric template by the putative P. anserina telomerase so that only a fraction of entering DNA is stabilized into linear extrachromosomal molecules. ..."

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