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Medical Definition of Somatic recombination
1. One of the mechanisms used to generate diversity in antibody production is to rearrange the DNA in B-cells during their differentiation, a process that involves cutting and splicing the immunoglobulin genes. Somatic recombination via homologous crossing over occurs at a low frequency in Aspergillus, Drosphilia and Saccharomyces and in mammalian cells in culture. It may be detected through the production of homozygous patches or sectors after mitosis of cells heterozygous for suitable marker genes. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)
Lexicographical Neighbors of Somatic Recombination
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