Definition of Ribonucleinase
1. Noun. A transferase that catalyzes the hydrolysis of ribonucleic acid.
Medical Definition of Ribonucleinase
Widely distributed type of enzyme that cleaves RNA. May act as endonucleases or exonucleases depending upon the type of enzyme. Generally recognise target by tertiary structure rather than sequence.
Ribonuclease E is involved in the formation of 5S ribosomal RNA from pre rRNA.
Ribonuclease F is stimulated by interferons and cleaves viral and host RNA and thus inhibits protein synthesis.
Ribonuclease H specifically cleaves an RNA base paired to a complementary DNA strand.
Ribonuclease P is an endonuclease that generate t RNA from their precursor transcripts.
Ribonuclease T is an endonuclease that removes the terminal AMP from the 3' CCA end of a nonaminoacylated tRNA. Ribonuclease T1 cleaves RNA specifically at guanosine residues. Ribonuclease TIII cleaves double stranded regions of RNA molecules.
(23 Aug 1998)
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