Medical Definition of Mitochondrial myopathies

1. Diseases of the muscles characterised by morphologic changes in mitochondria and often associated with excessive lipid accumulation. Muscle biopsies reveal "the presence of overly abundant and large mitochondria (often containing abnormal inclusions and cristae) in many muscle fibres. The terms mitochondrial and lipid storage have been used interchangeably to designate these myopathies, since the enzymes essential for intramuscular lipid metabolism are contained in the mitochondria, and a defect in the latter results in an abnormal accumulation of lipid bodies in muscle fibres." often defects in various oxidative enzymes figure. One type of mitochondrial myopathy is called pleoconial with reference to "a remarkably large number (pleo-) of enlarged mitochondria in the biopsied muscle", another is "called megaconial with reference to giant (mega-) mitochondria in the muscle." (adams and victor: principles of neurology, 2d ed, p980-1) (12 Dec 1998)

Lexicographical Neighbors of Mitochondrial Myopathies

mitises
mitobronitol
mitochondria
mitochondrial
mitochondrial DNA
mitochondrial chromosome
mitochondrial disease
mitochondrial encephalomyopathies
mitochondrial gene
mitochondrial genome
mitochondrial inheritance
mitochondrial intermediate peptidase
mitochondrial matrices
mitochondrial matrix
mitochondrial membrane
mitochondrial myopathies (current term)
mitochondrial oxidative damage endonuclease
mitochondrial swelling
mitochondrially
mitochondrion
mitochondrional
mitogen
mitogenesis
mitogenetic
mitogenic
mitogenicities
mitogenicity
mitogenome
mitogenomes

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