Medical Definition of Lod method

1. A method of linkage analysis using an examination of the common logarithm of the ratio of the likelihood for a particular value of the recombination fraction to that if the recombination fraction is 0.5 (i.e., no linkage); thus, a lod score of 3 at a recombination fraction of 0.2 means that the data are 1000 times more readily explained by supposing a recombination fraction of 0.2 than by supposing the loci are unlinked and the recombination fraction is 0.5. Origin: Logarithm of the odds (05 Mar 2000)



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lod method (current term)
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