Medical Definition of Isotype switching

1. The switch of immunoglobulin isotype that occurs, for example: as the immune response progresses (IgM to IgG). The switch from IgM to IgG involves only the constant region of the heavy chains (from _ to _), the light chain and variable regions of the heavy chain remaining the same and involves the switch regions, upstream (on the 5'side) of the constant region genes, at which recombination occurs. Similarly, IgM and IgD with the same variable region of the heavy chain, but with different heavy chain constant regions (_ and _), seem to coexist on the surface of some lymphocytes. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



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Lexicographical Neighbors of Isotype Switching

isotropic
isotropic disk
isotropic environment
isotropic lipid
isotropically
isotropies
isotropisation
isotropism
isotropization
isotropizations
isotropize
isotropized
isotropous
isotropy
isotype
isotype switching (current term)
isotyped
isotypes
isotypic
isotypic variation
isotypical
isourea
isoureas
isouric
isouric acid
isovalent
isovalently
isovaleric
isovaleric acid
isovaleric acidemia

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