Medical Definition of Iduronate sulfatase
1.
An enzyme that specifically cleaves the ester sulfate of iduronic acid, and is required for the desulfation of 2-sulfate iduronate residues in heparan sulfate. It is also required in dermatan sulfate degradation.
Its deficiency has been demonstrated in Hunter's syndrome, which is characterised by an excess of dermatan sulfate and heparan sulfate.
Chemical name: L-Iduronate-2-sulfate 2-sulfohydrolase
Registry number: EC 3.1.6.13
(20 Sep 2002)
Lexicographical Neighbors of Iduronate Sulfatase
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