Medical Definition of Experimental allergic encephalomyelitis

1. An autoimmune disease that can be induced in various experimental animals by the injection of homogenised brain or spinal cord in Freund's adjuvant. The antigen appears to be a basic protein present in myelin and the response is characterised by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Sometimes used as a model for demyelinating diseases, although whether this is entirely justifiable is not clear. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



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