Definition of Diltiazem

1. Noun. A calcium blocker (trade name Cardizem) used in treating hypertension or angina or heart failure.

Exact synonyms: Cardizem
Generic synonyms: Calcium Blocker, Calcium-channel Blocker
Language type: Trade Name



Definition of Diltiazem

1. Noun. A benzothiazepine drug, a potent vasodilator used to treat hypertension, migraine, angina pectoris, and some types of arrhythmia. ¹

¹ Source: wiktionary.com

Definition of Diltiazem

1. [n -S]

Medical Definition of Diltiazem

1. A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. It is also teratogenic. Pharmacological action: antihypertensive agents, calcium channel blockers, cardiovascular agents, teratogens, vasodilator agents. Direct, potent negative chronotrope with only mild negative inotropic effect; slows conduction in AV node; coronary vasodilation with less systemic vasodilation than verpamil. Chemical name: 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)- Uses: Control ventricular response with atrial fibrillation Dose: 0.25 mg/kg IV over 2 minutes May repeat at 0.35 mg/kg after 15 minutes. Maintenance infusion at 5 - 15 mg/hr. Potential complications: Less hypotension than with verapamil since less vasodilation and myocardial depression; bradycardia; may exacerbate AV block; synergistic interaction with beta blockers; relatively contraindicated with congestive heart failure. Note: Diltiazem can accelerate heart rate and decrease blood pressure, especially in patients with Wolff-Parkinson-White or wide-complex tachycardia. (15 Mar 2000)

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Lexicographical Neighbors of Diltiazem

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dilly dally
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dilogarithm
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diloxanide furoate
diltiazem (current term)
diltiazem hydrochloride
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dilutant
dilutants
dilute

Literary usage of Diltiazem

Below you will find example usage of this term as found in modern and/or classical literature:

1. 5th Report Of The Joint National Committee On Detection, Evaluation, And by DIANE Publishing Company (2004)
"Effects of beta-blockers on other drugs: * Combinations of diltiazem or verapamil with beta- blockers may have additive sinoatrial (SA) and arrio- ..."

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