Medical Definition of Chimeric/humanised antibody

1. Genetically engineered combination of a human and mouse antibody. Because a monoclonal antibody is always made with mice cells, it causes an immune response when injected into humans. By replacing the constant regions of a mouse antibody with those of a human antibody, an antibody that binds to an antigen like the original monoclonal antibody, but which is recognised by the human immune system like a human protein, can be manufactured. Alternatively, only those amino acids directly involved in antigen binding are transferred from the mouse antibody into the framework of the human antibody, with a similar result. (05 Jan 1998)

Lexicographical Neighbors of Chimeric/humanised Antibody

chime
chime in
chimed
chimelike
chimenea
chimeneas
chimer
chimera
chimeral
chimeralike
chimeraplast
chimeras
chimere
chimeres
chimeric
chimeric/humanised antibody (current term)
chimeric DNA
chimeric antibodies
chimeric antibody
chimeric molecule
chimeric proteins
chimerical
chimerically
chimerid
chimerids
chimerism
chimerisms
chimers
chimes
chimest

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